Jobs in Upstate SC

Move Up in Your Career

Looking for jobs in Upstate South Carolina? You’ve come to the right place.

The Upstate SC region is consistently ranked as one of the best places to live in the U.S. and combines a thriving job market with an affordable and vibrant quality of life. Whether you’re looking for jobs in Greenville, Spartanburg or other cities across the region, there’s no shortage of opportunity.

The Upstate South Carolina job board can help you connect with active job openings that match your skills and ambitions. Browse by industry or search by keyword to find opportunities with international brands, innovative start ups, top ranked healthcare providers and more.

Explore below to learn more about the top employers hiring in the region and find jobs in South Carolina’s most vibrant region.

Employers Hiring Now

Browse our major employers and click to view their current job openings.

Browse Upstate SC Jobs by Industry

Find job openings in your industry or explore all opportunities across the region.

Accounting + Finance

Have a way with numbers? Find a rewarding job in in-house accounting or at one of our major financial employers in Upstate SC.

View 720 Jobs

Biotechnology + Healthcare

From pharma and medical device manufacturing to healthcare, find a job to help improve the health of the world in Upstate SC.

View 1527 Jobs

Construction + Architecture + Engineering

Upstate South Carolina’s growing economy is built by construction, architecture and engineer professionals – literally.

View 1112 Jobs

Education

Home to 30 colleges and universities and excellent school systems, passionate teachers, professors and school administrators are in high demand in Upstate SC.

View 529 Jobs

Human Resources

Help people and workplaces achieve happiness, productivity and financial health with a career in human resources at one of Upstate SC’s global or growing companies.

View 248 Jobs

IT + Tech + Development

IT, technology and web development careers abound in Upstate SC, home to major tech and communications headquarters and growing startups.

View 399 Jobs

Manufacturing Production + Assembly

Manufacturers in Upstate SC craft products that keep the world moving. Find your dream role in automotive, aerospace, or a range of other specialties.

View 1193 Jobs

Marketing + Advertising + Sales

Tap into your creative side and use your flair for language to land a job in marketing, advertising or sales in Upstate SC.

View 632 Jobs

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Upstate Employment Services

Why Work in Upstate South Carolina?

Up your career and your lifestyle in Upstate South Carolina. With a strong, diverse economy and one of the most affordable costs of living in the Southeast, more professionals are finding their next big career step here.

Live and work in one of the country’s most vibrant, welcoming regions, surrounded by natural beauty, thriving communities, and a growing list of accolades.

But don’t just take our word for it. In the last two years, cities across Upstate SC have been named:

#1 Best City to Move in South Carolina (USA Today)
#1 Best City for Young Professionals in South Carolina (Niche)
#3 Most Beautiful & Affordable Place to Live (Travel & Leisure)
#4 Best Place to Live in the U.S. (U.S. News & World Report)
#4 Best Small City in the U.S. (Conde Nast)
#5 Top Cities to Move to (MoveBuddha)
Top 10 U.S. Food City (Travel & Leisure)

Top Industries Hiring in Upstate SC

Upstate South Carolina job openings span high-demand industries, including:

Manufacturing & Engineering — Work with global leaders like BMW and Michelin, or help build the next generation of clean energy, medical devices, and materials.
Healthcare & Life Sciences — Join top-ranked hospital systems, with in-demand roles for nurses, techs, administrators, and allied health professionals.
Technology & IT — From software development to cybersecurity, Upstate SC’s tech sector is growing rapidly.
Education — Schools and universities across the region are hiring educators, administrators, and support staff.
Finance & Business Services — Regional HQs and global firms are hiring in finance, HR, marketing, and operations.